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Oleaginous yeast are remarkably versatile organisms, distinguished by their natural capacities to accumulate high levels of neutral lipids and broad substrate range. With recent growing interests in engineering non-model organisms as superior biomanufacturing platforms, oleaginous yeasts have emerged as promising chassis for oleochemicals, terpenoids, organic acids, and other valuable products. Advancement in systems biology along with genetic tool development have significantly expanded our understanding of the metabolism in these species and enabled engineering efforts to produce biofuels and bioproducts from diverse feedstocks. This review examines the latest technical advances in oleaginous yeast research toward sustainable biomanufacturing. We cover recent developmentsmore » in systems biology-enabled metabolism understanding, genetic tools, feedstock utilization, and strain engineering approaches for the production of various valuable chemicals.« less

The exploration of intriguing topological quantum physics in stanene has attracted enormous interest but is challenged by lacking desirable material samples. The successful fabrication of monolayer stanene on PbTe(111) films with low-temperature molecular beam epitaxy and thorough characterizations of its atomic and electronic structures are reported here. In situ angle-resolved photoemission spectroscopy together with first-principles calculations identify two hole bands of p _xy orbital with a spin-orbit coupling induced band splitting and meanwhile reveal an automatic passivation of p _z orbital of stanene. Importantly, material properties are tuned by substrate engineering, realizing a decorated stanene sample with truly insulating bulkmore » on Sr-doped PbTe. In conclusion, this finding paves a road for studies of stanene-based topological quantum effects and electronics.« less